4D Characterization of Short- and Long-term Height-varying Decorrelated Forest SAR Backscattering

Pol-InSAR and 3D multibaseline SAR Tomography (Tomo-SAR) can extract rich information on complex scenarios with multiple scatterers mapped in the SAR cell, in particular for forest remote sensing. However, forest scenarios are characterized by a temporal decorrelating volume canopy scatterer, and a set of related open problems exists, in particular for Tomo-SAR techniques to be applied to spaceborne monitoring of biomass. Multipass 4D Differential Tomography (Diff-Tomo) is a promising advancement, furnishing space (height)-time signatures of multiple scatterer dynamics in the SAR cell, originally with urban applications. In this paper, to better characterize forest decorrelation phenomena impacting Tomo-SAR/Pol-InSAR, experimental results are presented of the extension of Diff-Tomo methods for analyzing vegetated scenes, to extract jointly geometric and dynamic information of forest layers, at both the long and short time scale. The Diff-Tomo enabled functionality of separation in the height dimension of different temporal coherence levels (“coherence profilingâ€) that are mixed (undiscriminated) in classical total coherence analyses is extensively applied to airborne P-band multipolarimetric data, and results of this investigation are shown. Also, first ground-based radar results are presented of an innovative profiling along the height dimension of the short-term coherence, in particular aiming to characterize the magnitudes of short-term coherence times. Their expected variability along the tree structures is confirmed for the first time

Single-look light-burden superresolution differential SAR tomography

Research and application is spreading of techniques of coherent combination of complex-valued synthetic aperture radar (SAR) data to extract rich information even on complex observed scenes, fully exploiting existing SAR data archives, and new satellites. Among such techniques, SAR tomography stems from multibaseline interferometry to achieve full-3D imaging through elevation beamforming (spatial spectral estimation). The Tomo concept has been integrated with the mature differential interferometry, producing the new differential tomography (Diff-Tomo) processing mode, that allows `opening' the SAR cells in complex non-stationary scenes, resolving multiple heights and slow deformation velocities of layover scatterers. Consequently, the operational capability limit of differential interferometry to the single scatterer case is overcome. Diff-Tomo processing is cast in a 2D baseline-time spectral analysis framework, with sparse sampling. The use of adaptive 2D spectral estimation has demonstrated to allow joint baseline-time processing with reduced sidelobes and enhanced height-velocity resolution at low computational burden. However, this method requires coherent multilooking processing, thus does not produce full range-azimuth resolution products, as it would be desirable for urban applications. A new single-look adaptive Diff-Tomo processor is presented and tested with satellite data, allowing full range-azimuth resolution together with height-velocity sidelobe reduction and superresolution capabilities and the low computational burden

Effects of a subadiabatic layer on convection and dynamos in spherical wedge simulations

We consider the effect of a subadiabatic layer at the base of the convection zone on convection itself and the associated large-scale dynamos in spherical wedge geometry. We use a heat conduction prescription based on the Kramers opacity law which allows the depth of the convection zone to dynamically adapt to changes in the physical characteristics such as rotation rate and magnetic fields. We find that the convective heat transport is strongly concentrated toward the equatorial and polar regions in the cases without a substantial radiative layer below the convection zone. The presence of a stable layer below the convection zone significantly reduces the anisotropy of radial enthalpy transport. Furthermore, the dynamo solutions are sensitive to subtle changes in the convection zone structure. We find that the kinetic helicity changes sign in the deeper parts of the convection zone at high latitudes in all runs. This region expands progressively toward the equator in runs with a thicker stably stratified layer.Comment: 32 pages, 18 figures, accepted to GAFD Special issue on 'Recent Developments in Natural Dynamos

Multi-Sensor UAV Application for Thermal Analysis on a Dry-Stone Terraced Vineyard in Rural Tuscany Landscape

Italian dry-stone wall terracing represents one of the most iconic features of agricultural landscapes across Europe, with sites listed among UNESCO World Heritage Sites and FAO Globally Important Agricultural Heritage Systems (GIAHS). The analysis of microclimate modifications induced by alterations of hillslope and by dry-stone walls is of particular interest for the valuation of benefits and drawbacks of terraces cultivation, a global land management technique. The aim of this paper is to perform a thermal characterization of a dry-stone wall terraced vineyard in the Chianti area (Tuscany, Italy), to detect possible microclimate dynamics induced by dry-stone terracing. The aerial surveys were carried out by using two sensors, in the Visible (VIS) and Thermal InfraRed (TIR) spectral range, mounted on Unmanned Aerial Vehicles (UAVs), with two different flights. Our results reveal that, in the morning, vineyard rows close to dry-stone walls have statistically lower temperatures with respect to the external ones. In the afternoon, due to solar insulation, temperatures raised to the same value for each row. The results of this early study, jointly with the latest developments in UAV and sensor technologies, justify and encourage further analyses on local climatic modifications in terraced landscapes

Secondary malignant neoplasms, progression-free survival and overall survival in patients treated for Hodgkin lymphoma: A systematic review and meta-analysis of randomized clinical trials

Treatment intensification to maximize disease control and reduced intensity approaches to minimize the risk of late sequelae have been evaluated in newly diagnosed Hodgkin lymphoma. The influence of these interventions on the risk of secondary malignant neoplasms, progression-free survival and overall survival is reported in the meta-analysis herein, based on individual patient data from 9498 patients treated within 16 randomized controlled trials for newly diagnosed Hodgkin lymphoma between 1984 and 2007. Secondary malignant neoplasms were meta-analyzed using Peto\ue2\u80\u99s method as time-to-event outcomes. For progression-free and overall survival, hazard ratios derived from each trial using Cox regression were combined by inverse-variance weighting. Five study questions (combined-modality treatment vs. chemotherapy alone; more extended vs. involved-field radiotherapy; radiation at higher doses vs. radiation at 20 Gy; more vs. fewer cycles of the same chemotherapy protocol; standard-dose chemotherapy vs. intensified chemotherapy) were investigated. After a median follow-up of 7.4 years, dose-intensified chemotherapy resulted in better progression-free survival rates (P=0.007) as compared with standard-dose chemotherapy, but was associated with an increased risk of therapy-related acute myeloid leukemia/myelodysplastic syndromes (P=0.0028). No progression-free or overall survival differences were observed between combined-modality treatment and chemotherapy alone, but more secondary malignant neoplasms were seen after combined-modality treatment (P=0.010). For the remaining three study questions, outcomes and secondary malignancy rates did not differ significantly between treatment strategies. The results of this meta-analysis help to weigh up efficacy and secondary malignancy risk for the choice of first-line treatment for Hodgkin lymphoma patients. However, final conclusions regarding secondary solid tumors require longer follow-up

Long‐term overall survival and toxicities of ABVD vs BEACOPP in advanced Hodgkin lymphoma: A pooled analysis of four randomized trials

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Pour une démocratie socio-environnementale : cadre pour une plate-forme participative « transition écologique »

Contribution publiée in Penser une démocratie alimentaire Volume II – Proposition Lascaux entre ressources naturelles et besoins fondamentaux, F. Collart Dutilleul et T. Bréger (dir), Inida, San José, 2014, pp. 87-111.International audienceL’anthropocène triomphant actuel, avec ses forçages environnementaux et sociaux, est à l’origine de l’accélération des dégradations des milieux de vie sur Terre et de l’accentuation des tensions sociales et géopolitiques. Passer à un anthropocène de gestion équitable, informé et sobre vis-à-vis de toutes les ressources et dans tous les secteurs d’activité (slow anthropocene), impose une analyse préalable sur l’ensemble des activités et des rapports humains. Cette transition dite « écologique », mais en réalité à la fois sociétale et écologique, est tout sauf un ajustement technique de secteurs dits prioritaires et technocratiques. Elle est avant tout culturelle, politique et philosophique au sens propre du terme. Elle est un horizon pour des trajectoires de développement humain, pour des constructions sociales et économiques, censées redéfinir socialement richesse, bien-être, travail etc. La dénomination « transition écologique » est largement véhiculée, mais ses bases conceptuelles ne sont pas entièrement acquises ni même élaborées. Dans ce contexte, les étudiants en première année de Master BioSciences à l’Ecole Normale Supérieure (ENS) de Lyon ont préparé une première étude analytique de ce changement radical et global de société pour mieux comprendre dans quelle société ils souhaitent vivre, en donnant du sens aux activités humaines présentes et à venir. Une trentaine de dossiers sur divers secteurs d’activités et acteurs de la société ont été produits et ont servis de support à cette synthèse. Plus largement, le but est de construire un socle conceptuel et une plate-forme de travail sur lesquels les questions de fond, mais aussi opérationnelles, peuvent être posées et étudiées en permanence. Cette démarche participative est ouverte à la collectivité sur le site http://institutmichelserres.ens-lyon.fr/

Evaluation of the prognostic value of impaired renal function on clinical progression in a large cohort of HIV-infected people seen for care in Italy

Whilst renal dysfunction, especially mild impairment (60 die;ve (Icona) Foundation Study collected between January 2000 and February 2014 with at least two creatinine values available. eGFR (CKD-epi) and renal dysfunction defined using a priori cut-offs of 60 (severely impaired) and 90 ml/min/1.73m2 (mildly impaired). Characteristics of patients were described after stratification in these groups and compared using chi-square test (categorical variables) or Kruskal Wallis test comparing median values. Follow-up accrued from baseline up to the date of the CCVD or AIDS related events or death or last available visit. Kaplan Meier curves were used to estimate the cumulative probability of occurrence of the events over time. Adjusted analysis was performed using a proportional hazards Cox regression model. We included 7,385 patients, observed for a median follow-up of 43 months (interquartile range [IQR]: 21-93 months). Over this time, 130 cerebro-cardiovascular events (including 11 deaths due to CCVD) and 311 AIDS-related events (including 45 deaths) were observed. The rate of CCVD events among patients with eGFR >90, 60-89, <60 ml/min, was 2.91 (95% CI 2.30-3.67), 4.63 (95% CI 3.51-6.11) and 11.9 (95% CI 6.19-22.85) per 1,000 PYFU respectively, with an unadjusted hazard ratio (HR) of 4.14 (95%CI 2.07-8.29) for patients with eGFR <60 ml/min and 1.58 (95%CI 1.10-2.27) for eGFR 60-89 compared to those with eGFR ≥90. Of note, these estimates are adjusted for traditional cardiovascular risk factors (e.g. smoking, diabetes, hypertension, dyslipidemia). Incidence of AIDS-related events was 9.51 (95%CI 8.35-10.83), 6.04 (95%CI 4.74-7.71) and 25.0 (95% CI 15.96-39.22) per 1,000 PYFU, among patients with eGFR >90, 60-89, <60 ml/min, respectively, with an unadjusted HR of 2.49 (95%CI 1.56-3.97) for patients with eGFR <60 ml/min and 0.68 (95%CI 0.52-0.90) for eGFR 60-89. The risk of AIDS events was significantly lower in mild renal dysfunction group even after adjustment for HIV-related characteristics. Our data confirm that impaired renal function is an important risk marker for CCVD events in the HIV-population; importantly, even those with mild renal impairment (90<60)&gt